Resistance training load does not determine hypertrophy

(onlinelibrary.wiley.com)

57 points | by Luc 4 hours ago

14 comments

  • AstroBen 2 hours ago
    > Healthy, recreationally active but untrained young males

    Yeah this is why. Anything you do as an untrained person is going to get you newbie gains. It's just really easy to improve initially. Doesn't mean it'll work after the first 6 months

  • armcat 2 hours ago
    I thought it was already well understood/researched that it's not the weights that matter, but effectively taking your sets to muscular failure. While one might think "I can do 50 reps with low weights" there is practical aspects to this - you don't wand to spend hours at the gym, and doing heavy weights at 5-7 reps is sufficient as long as you are close or at muscular failure.
    • xnx 2 hours ago
      Well understood, but not widely known. The myths and superstitions around anything health related are frustratingly durable.
    • kace91 2 hours ago
      >While one might think "I can do 50 reps with low weights"

      The caveat is that you need anaerobic training. Low enough weight and it’s cardio, you don’t get giant legs by walking to failure for example.

    • fudged71 35 minutes ago
      Brad Schoenfeld Has been on this body of work for a long time, and he is "Mr. Hypertrophy" in the field. So yes
    • elevaet 2 hours ago
      What about the old gym adage "training to failure is failing to train" - is there any physiological basis for this, or is it mental, or just a myth?
      • wswope 2 hours ago
        That’s a Pl/Oly mindset rather than a BB/hypertrophy mindset. Totally valid advice in the right context.

        Long story short, failed reps get much more risky and problematic as the weight you’re lifting approaches your 1RM.

      • nzeid 48 minutes ago
        It's definitely way more nuanced than that. You have to approach exhaustion to get the body to eventually build strength. But you need to carefully time your rests/deloads and handle plateaus with more volume.
      • kace91 2 hours ago
        I’ve never heard that, it’s usually the opposite- people do strip sets and the like to reach failure
      • teecha 1 hour ago
        not an expert, 2 years of serious lifting, but this is probably a good adage for the average person from my current understanding

        training to failure puts you at higher risk of injury and there are diminishing returns as you approach your 1 rep max and/or failure

        hypertrophy can happen with more reps or more weight

        strength gains are usually just focused on progressive overload

        though, of course, hypertrophy will happen either way and contributes to increased strength, but this seems to be further confirmation that you can gain muscle size either way

    • amelius 2 hours ago
      How about making muscles fail by stretching them under load?
      • mrob 2 hours ago
        Depending on what you mean by "fail" and "stretching", that sounds a lot like eccentric training [0] (a.k.a. "negatives"). It's effective but notorious for causing delayed onset muscle soreness.

        I trained myself to do pull-ups using this method, repeatedly lowering myself in a controlled motion from the top position while I was too weak to actually pull myself up.

        [0] https://en.wikipedia.org/wiki/Eccentric_training

      • jimbo808 2 hours ago
        Sounds like a great way to injure yourself, also would only work for eccentric motion
        • amelius 2 hours ago
          To me it doesn't sound much different than "taking your sets to muscular failure".
          • jimbo808 1 hour ago
            Not all muscles resist extension, some do the opposite and contract.
    • vasco 1 hour ago
      > Loads for each set were adjusted to ensure that volitional fatigue was reached within 8–12 and 20–25 repetitions for the HL and LL limbs, respectively

      I would argue both categories of the study are about low reps. I don't see how the body would tell the difference between 12 and 25 reps. If you said between 5 and 500, like it has to meaningfully take much longer, otherwise why would doing something so similar have any meaningful difference?

      The way I think about it is that nature mostly reacts to order of magnitude changes. 12 to 25 is the same thing.

      Like why not make a study to see if its more nutritious to eat dinner in 15 or 20 minutes?

      • pjc50 1 hour ago
        This is spoken like you've never done any reps at all?
        • vasco 1 hour ago
          There's not much difference in hitting max at 12 and at 25, from anecdotal experience. The study corroborated that as well, even though with small n.
      • mnky9800n 1 hour ago
        I feel like I would definitely notice if I went from 12 to 25 reps on any exercise I do. Although typically I max out at 8 before adding more weight.
  • weinzierl 2 hours ago
    If I read this correctly the gist is that it does not matter if you use heavy weights with few reps (common body builder wisdom) or lighter weights with more reps. As long as you always exercise to complete muscle fatigue you'll get the maximum for your genetics (which itself varies a lot).
    • bob1029 44 minutes ago
      There's no way this works in practice. A lot of heavy lifting (maximums) is about neurology and mind-body training. You cannot develop the ability to deadlift 405lbs by spending 2 hours using a cable crossover machine every day. Picking up something that weighs 2x more than you do requires your brain to send an extremely strong, synchronized signal. This is something that takes a lot of practice to develop. You have to consistently push your maximum voluntary effort in order to expand this capacity.
      • jjj123 39 minutes ago
        Right, but this post is about hypertrophy (big muscles). Not about heavy lifts.
        • bob1029 25 minutes ago
          Well one thing can lead into the other over time. If you can lift 405 once, 315 for reps becomes pedestrian and 225 becomes boring. Lifting that much weight will turn you into a monster faster than if you had not pushed for that capacity. I've seen people who can treat a 225lb barbell as if it's unloaded and 100% of them look like dragon ball Z characters.
    • toomuchtodo 2 hours ago
      Can we replicate the process of reaching muscle fatigue/failure to spur muscle growth without the strength training or anabolic steroids? Think GLP-1RAs but for this specific biological pathway.

      https://www.biopharmadive.com/news/lilly-terminate-obesity-t...

      https://www.sciencedirect.com/topics/medicine-and-dentistry/...

      • allan_s 1 hour ago
        My understanding is that anabolic steroid are somehow close to what you're thinking about? It's just that as anything taking a simple shortcut , it comes with unwanted effects
    • zemvpferreira 2 hours ago
      It’s worth noting that muscle is not all the same. If you’re just into bodybuilding then sure, proximity to failure is what matters. For athletics though, there still seems to be a big impact in the rep range you work in.
      • d-us-vb 2 hours ago
        This. Muscles can be optimized for volume/endurance or power, or some balance between them. Taking legs as an example: Powerlifters obviously go for pure power, whereas runners need a bit of power but mostly endurance, whereas cyclists need more power than runners but more endurance than powerlifters.

        All of these benefit from weight training, but depending on the sport, the programming will be very different.

        • allan_s 1 hour ago
          I think I know where they're coming from as I used to have a similar wrong model. I thought strength = more muscle cells and endurance = just better heart/lungs to deliver oxygen and clear waste like CO2 and lactic acid.

          Turns out muscle fibers mostly grow bigger rather than more numerous, and there are different fiber types (slow-twitch vs fast-twitch) that adapt based on how you train. So for the same muscle, an Ironman runner and a guy doing heavy low-rep squats will develop different fiber characteristics: you can't fully max out both.

          I'm simplifying, but learning this changed a lot about how I understand exercise at the biological level.

    • rorytbyrne 1 hour ago
      > heavy weights with few reps (common body builder wisdom)

      It is strength training (not body builder) wisdom to use heavy weights with few reps. Hypertrophy (i.e. body builder) programmes usually call for 8-12 reps, which implies relatively low weights.

      • NooneAtAll3 1 hour ago
        is "8-12" not "few" for you?
        • rorytbyrne 48 minutes ago
          Relatively speaking, no. Strength training (as opposed to hypertrophy) calls for fewer reps, around 5 per set.

          Many people advise spending about a year doing more sets of fewer (~5) reps to build strength, and then switch to fewer sets of more reps (8-12) when you want to build muscle mass.

          Point being, the idea of doing lighter weights until failure is already kind of there in body building wisdom.

        • SoftTalker 36 minutes ago
          3-5 reps per set for powerlifting training. Competition lifts are a single rep.
        • throwaway6734 37 minutes ago
          1-3 is few
    • kace91 2 hours ago
      It is actually common bodybuilder wisdom to go for the lighter version.

      Stereotyping, weightlifters who go for max numbers do 1 set of a million pounds and rest three hours between exercises, while bodybuilders do thirty exercises a day for 8 series of 15 reps each.

    • MattRix 1 hour ago
      Unless I’m missing something, this has already been known, though the hypertrophic benefits start to reduce beyond 30 reps.
  • Imanari 1 hour ago
    For beginner lifters that might be true initially, but eventually weight will matter.
  • Analemma_ 2 hours ago
    I know it's practically de rigeur to jump into the comments and immediately complain about methodology for any study that makes it to the front page, and I want to emphasize I don't distrust their findings, but I would like to see an equivalent study go out longer than 10 weeks. When I've been taking weightlifting seriously I feel like I don't even start to notice hypertrophy until 8-10 weeks. I feel like 6 months is the actual period where results would matter, to me, but I assume "subject compliance" is pretty difficult to get for such a timeframe, if you're really watching dietary intake and ensuring subjects go to failure (which, to its credit, this study did).
    • mf_tomb 2 hours ago
      This is par for the course with exercise science. It's mostly fake. No blinding, small sample sizes, researchers with agenda, low duration, low funding etc. The good news is that doing almost anything works.
  • bethekidyouwant 2 hours ago
    The group that did lower reps with higher weight, had the better one rep max at the end of the study, but they didn’t measure if the higher rep group had greater endurance. Which seems a bit odd, considering their conclusion is both groups grew the same amount of muscle which fine but if the muscle is adapted for something different in each group, you would want to capture that.
  • mmmilanooo 2 hours ago
    It does matter. It's the only objective way to measure progress. A study doesn't negate that.
    • yjftsjthsd-h 1 hour ago
      I don't think so? If last week I could do 50 reps @ 5 lbs, and this week I can do 50 at 6 lbs (or 60 at 5lbs), then that's measurable objective progress
    • justatdotin 2 hours ago
      isnt the 1RM the measure of progress?
      • SoftTalker 32 minutes ago
        If that's what you're training for, sure. If you just want to be strong, you can achieve that and avoid the highest injury risk by sticking with 5 reps or so.
  • Sporktacular 2 hours ago
    So resistance is futile?
  • cubefox 2 hours ago
    > Twenty healthy young male participants completed thrice-weekly resistance exercise sessions for 10 weeks.

    Not sure how much can be concluded from this.

  • Torkel 2 hours ago
    I.e.

    No pain, no gain.

    • slashtmpslashme 6 minutes ago
    • cyberax 2 hours ago
      This is really terrible advice that just discourages people.

      You absolutely can get significant improvements without (much) pain. DOMS during the initial stages is going to be the most uncomfortable part. Once you're past it, you don't need to push yourself to a breaking point, just to the point of mild exhaustion.

      This will provide you enough resistance to gain muscle mass and improve the bone density to healthy levels.

      • strken 1 hour ago
        Yeah, "no pain no gain" is probably the worst advice I've ever received. It encourages sedentary people to go hard for a week and then quit, which is the exact opposite of what works: starting with consistent easy sessions and adding progressive overload.

        Dynomight has a good blog post about this[0], but applied to running rather than resistance training.

        [0] https://dynomight.net/2021/01/25/how-to-run-without-all-the-...

  • carnufex 12 minutes ago
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  • lifetimerubyist 2 hours ago
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  • hazard 2 hours ago
    tldr appears to be that if you work to fatigue it doesn't matter if you fatigue out with high weights vs low weights
    • andoando 16 minutes ago
      There is certainly a difference in a slow twitch vs fast twitch muscle adaptation though

      https://pmc.ncbi.nlm.nih.gov/articles/PMC8139349/

    • vlod 2 hours ago
      I agree with this, but for those newbies be careful at what you define as "failure".

      I've f.up my MCL by not listening to my body and I have the stability of a typical 85 year old while I try and 'heal'. It takes longer as you get older (you're probably not 20 year old) and stupid stuff can really take you out.

    • teecha 1 hour ago
      fairly new to lifting myself (2+ years taking it seriously) but this thing seems to jive with what I've read across different areas

      bodybuilders can build muscle size with high reps and lower weight or lower reps and high weight as long as they do it close to failure with only a few reps in reserve (rir)

      powerlifters, or those focusing on strength, usually go for high weight and lower reps because they might be training for a competition that focuses on 1 rep max and/or the body can really only handle so many reps when pushing it at 80-90% of 1 rep max

      neither is inherently better but a matter of what goals you have in mind, plus, hypertrophy contributes to overall strength, too

    • chrishare 2 hours ago
      When training for muscle size atleast, but not strength. Presumably there are increased injury risks overall when lifting heavy (based on a brief search).
  • amelius 2 hours ago
    Wait, why are we figuring this out only now?
    • overhead4075 2 hours ago
      A paper doesn't necessarily mean the information is new, but that there is now some/more evidence to support it.
      • amelius 1 hour ago
        True, but this kind of information is so basic it almost fits in the "world is round" category.