Let's assume that you mean activation patterns at the level of single cells. Aside from the ethical issues which make it virtually impossible to obtain the full set of data, there is also the fact that the exact timing of expression is one of the major ways in which development produces variability in phenotype and so can vary wildly between individuals. The closest we have right now might be HUBMAP [0] or HCA [1], but I don't think that those had as objectives covering multiple developmental timepoints.
Hey, $DEITY did its absolute best with the constraints and the requirements. But hey, can't please everyone apparently. Be happy you can relieve yourself well past the intended warranty period. The parts were designed to be easily _aftermarket_ replaceable with sufficient advances in technology, retaining the fundamental design without changes.
Separation of functions/concerns is not great, for starters.
The testes are dangerously exposed, the plumbing is convoluted and failure-prone (and doesn’t recover well from mechanical insults).
The prostate, which serves no function outside of reproduction, lies inline with the urethra and quite consistently loses flexibility and becomes enlarged with age, causing all sorts of structural issues impacting basic urological function.
Female reproductive vs urinary anatomy is largely physiologically distinct (proximity and UTI risk notwithstanding). Though plenty of room for improvement there too — starting with endometrial tissue being far too prolific. Fun fact: endometrial tissue can migrate to the brain and cause haemorrhaging in severe cases of endometriosis.
Plenty of room for improvement across the board, I’d say!
I fail to see that, it's simply one of all other random mutations, it's just that this one has a big downstream effect of enabling other more complex mutations
> The most successful at communicating their view that they are the most successful
To who? Other humans?
It's seagull mating season where I am, and I don't speak seagull, but I'm pretty sure one of the things they're trying to convey to their fellow seagulls is that they're extremely successful.
Can't argue with it either. They're very much alive, which is the best you can be in this particular competition.
Corn, albeit not an animal has been pretty successful in terms of number of individuals. Their bi-pedal underlings have cleared swathes of land and take meticulous care of their well-being so they can bask in the sun undisturbed.
So, the most successful at arrogance? In other words, the least successful at humility? Ironically, since humble and human share a common root. Just playing devil's advocate here, but what you propose is not a good metric to maximize.
Arguably much less successful since jellyfish have been around 700+ million years ands it’s not clear if humans will make it even the next couple thousand.
But the jury is still out on that one
Anyone know of a resource that layouts the temporal activation patterns for all the genes for the life cycle of a human being?
0. https://portal.hubmapconsortium.org/ 1. https://data.humancellatlas.org/
> It's not an obvious problem in lots of ways.
Care to expand on this?
Link for others:
https://www.science.org/doi/10.1126/science.abl4896
https://maayanlab.cloud/Harmonizome/dataset/Tabula+Sapiens+G...
And if we ran an experiment where we gave it to some apes…
Really, the likelihood is that these mutations must have had an impact that far outweighs their space in the genome.
That’s how all our close competition got murdered by Homo Sapiens. Just significant difference in mental abilities.
I think its rather some mutations that produced more reelin and created the most successful animal in earth's history
The testes are dangerously exposed, the plumbing is convoluted and failure-prone (and doesn’t recover well from mechanical insults).
The prostate, which serves no function outside of reproduction, lies inline with the urethra and quite consistently loses flexibility and becomes enlarged with age, causing all sorts of structural issues impacting basic urological function.
Female reproductive vs urinary anatomy is largely physiologically distinct (proximity and UTI risk notwithstanding). Though plenty of room for improvement there too — starting with endometrial tissue being far too prolific. Fun fact: endometrial tissue can migrate to the brain and cause haemorrhaging in severe cases of endometriosis.
Plenty of room for improvement across the board, I’d say!
aaand we have Quake and Comand&Conquer - Red Alert
Agreed, it would seem that evolutionary biology peaked in the late 90s then
Has another animal proposed they are more successful by a different metric?
Crickets?
To who? Other humans?
It's seagull mating season where I am, and I don't speak seagull, but I'm pretty sure one of the things they're trying to convey to their fellow seagulls is that they're extremely successful.
Can't argue with it either. They're very much alive, which is the best you can be in this particular competition.
Really interesting article though. I’m very hopeful AI can help work out how all these things interact.